Brain Network Breakdown: The Effects of Serotoninergic Psychedelics • There have been studies conducted on the effects of classic serotoninergic psychedelics like LSD, psilocybin, and MDMA. • A recent fMRI study was done on DMT. • One emerging principle is the breakdown in the integrity of brain networks when taking these psychedelics. • This breakdown is observed in various major brain networks, particularly in high-level brain networks. Transcript: Speaker 3 What do you think is happening in the brain at this point, Robin, when we take one of the classic serotoninergic psychedelics, LSD, psilocybin, I mean, I’d be interested to know how To do it. I’d be interested to know what you think is happening with MDMA as well. But I think you said you did an FMRI study on DMT too. Give me the mapping that we are reasonably confident at this point. Speaker 2 Yeah, I think it’s fair to say we’re reasonably confident now because we’ve had, personally, I’ve done three studies with three classics. DMT was the most recent. And so there are some principles that are emerging. One of them is that if we look at brain networks, which is more the way that we think of human brain function and making mappings to high level cognition and conscious states, we’re much More thinking about brain networks now. They’re dynamics. And there we see that across the board with psilocybin, LSD, DMT, you see a breakdown in the integrity of brain networks. And this is actually quite true across a repertoire of major brain networks, but especially so in high level brain networks, networks (Time 1:03:12)