Increasingly, observers question whether schizophrenia is strictly a genetic disorder. Beginning in 1996 NIMH began shifting its research resources from clinical studies to basic research based on the promise of the Human Genome Project. Consequently, three decades later NIMH’s genetics investment has yielded almost nothing clinically useful for individuals currently affected. It is time to review NIMH’s schizophrenia research portfolio (View Highlight)
The bulk of research evidence suggests that genetics plays a role in the etiology and that genetic alterations are causally relevant for some patients, but genetic factors appear to be neither necessary nor sufficient for the development of schizophrenia, which makes it difficult to justify schizophrenia as primarily a “genetic disorder” (or even primarily a disorder of gene-environment interactions). (View Highlight)
genética esquizofrenia causas psiquiatría
Psychiatric symptoms appear to be dimensionally distributed in populations, such that psychiatric syndromes are better understood as extremes on continua. And categories such as schizophrenia likely represent the intersection of multiple continua. (View Highlight)